Prolonged use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.Дo not exceed the daily dose, increasing it or more prolonged treatment is possible only under medical supervision, because overdose of the drug can cause liver failure. The duration of intake without consulting a physician not more than 5 days when administered as an analgesic and 3 days - as a febrifuge. Used inside adults and children over 15 years: 1 tablet 2-3 The maximum single dose for adults is 2 tablets, 4 tablets daily. Infectious and inflammatory diseases accompanied by fever. Headache, toothache, migraine headache

Spasm of smooth muscles of internal organs Indications for use of the drug Trigano-D About 80% of the drug excreted in the urine and in small numbers in the faeces. Paracetamol is metabolized in the liver with the formation of several metabolites, one of which is N-acetyl-benzohinomin under certain conditions (an overdose of medication, lack of glutathione in the liver) could have a damaging effect on the liver and kidneys. C max plasma levels achieved after 60-90 min. The drug is well absorbed in the gastrointestinal tract. The combined effect of two components Trigano-D provides a relaxation spasm of smooth muscles of internal organs and reducing pain. At therapeutic doses, is effective relaxation of smooth muscles, which is not accompanied by side effects typical of atropine. The second component ditsikloverina tertiary amine hydrochloride, which has a relatively weak non-selective M-anticholinergic and direct miotropnym antispasmodic effect on smooth muscles of internal organs. The mechanism of action is associated with a moderate inhibition of cyclooxygenase-1 and to a lesser extent COX-2 in peripheral tissues and central nervous system, resulting in the inhibition of prostaglandin biosynthesis modulators of pain sensitivity, thermoregulation and inflammation. Incoming in the drug paracetamol has analgesic, antipyretic and anti-inflammatory effects negligible. Storage: Store in dark place at a temperature of 15-25 В° C Accelerate the elimination of pseudoephedrine can be accelerated by diuresis or dialysis. After the departure should wash out the stomach, activated charcoal to appoint, with the development of seizures - anticonvulsants. In case of overdose should support respiration and the cardiovascular system. OVERDOSE: can manifest mydriasis, tachycardia, AH, cardiac arrhythmia, agitation, hallucinations (usually in children), nausea and vomiting, hypertensive crisis, insomnia, muscle tremors, change in mental status. INTERACTION: with caution appointed concurrently with antihypertensive drugs, MAO inhibitors, tricyclic antidepressants, sympathomimetic. Precautions should be considered in patients with diabetes, cardio-vascular diseases, hyperthyroidism, increased intraocular pressure, prostatic hypertrophy, as well as with severe disorders of the liver and kidneys.

SIDE EFFECTS: drowsiness, sometimes - itching, tachycardia, dry mouth, nose, throat.Д¬autions: efficacy and safety of drugs during pregnancy and lactation are not well understood. Tablets are not recommended to be used in children under the age of 12 years.Д¬ONTRAINDICATIONS: Hypersensitivity to any component of the drug, severe hypertension and coronary artery disease, the application for the last 2 weeks of MAO inhibitors, pregnancy and lactation, age up to 6 months. USE: Adults and children over the age of 12 years - 10 ml of syrup or 1 tablet 3 times a day, from 6 months to 2 years - on 1.25 ml of syrup 3 times daily, 2-5 years - 2, 5 ml syrup 3 times a day, 6-12 years - 5 ml syrup 3 times a day. INDICATIONS: Symptomatic treatment of upper respiratory tract, rhinitis, including allergic and vasomotor rhinitis, rhinitis with colds. The output in the form of metabolites with feces. The components of the drug rapidly and almost completely absorbed in the digestive tract. Pseudoephedrine - systemically acting decongestants, sympathomimetic, a stimulant О±-and ОІ-adrenergic receptors. Triprolidin is an antagonist of H 1-receptor is used as a means of reducing symptomatic symptoms caused by the release of histamine.

Pharmacological properties: a combined systemic effects of decongestants, applied in the pathology of the nasal cavity.

Trigan d in pregnancy